Cancer Keys: Myeloma and C.R.A.B
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Welcome to Cancer Keys, a regular bite-sized learning column brought to you by GatewayC in collaboration with Cancer Research UK.
Myeloma and C.R.A.B
C.R.A.B is the acronym designed to simplify the most typical clinical manifestations of multiple myeloma. Clinicians should consider the following indicators in a potential myeloma diagnosis:
C: Calcium – hypercalcaemia
R: Renal – any form of renal dysfunction
A: Anaemia (of unknown cause)
B: Bone – unexplained and persistent bone pain (often back pain)
NICE NG12 guidelines advise that a very urgent protein electrophoresis and Bence-Jones protein urine test (within 48 hours) for patients with hypercalcaemia or leukopenia and a presentation that is consistent with myeloma.