Cancer Keys: PPIs masking red flag symptoms for stomach cancer

Proton Pump Inhibitors (PPIs) are widely used to treat acid reflux and dyspepsia. NICE cautions that PPIs can mask or alter symptoms of stomach cancer, leading to later diagnoses.

Potential Pitfall

Patients on PPIs who have developed stomach cancer may increase their doses to manage further acid reflux and dyspepsia, further masking red flag symptoms. However, symptoms may become resistant or alter in character – perhaps manifesting as pain rather than burning, for instance.

Helpful hint

NICE NG12 guidelines advise to consider non‑urgent direct access upper gastrointestinal endoscopy to assess for stomach cancer in people aged 55 or over with treatment‑resistant dyspepsia.

Offer urgent direct access upper gastrointestinal endoscopy (to be performed within 2 weeks) to assess for stomach cancer in people with dysphagia, or aged 55 and over with weight loss and any of the following: upper abdominal pain, reflux, dyspepsia.

Cancer Keys are brought to you by GatewayC.

Download this Cancer Key here

Access GatewayC’s course on early diagnosis of stomach cancer here.

LinkedIn Twitter Facebook

Latest from the Blog

Cancer Keys: Rectal bleeding

Cancer Keys: Rectal bleeding

Potential pitfall: Rectal bleeding is a key symptom of colorectal cancer, but there are also a number of other benign causes. Tumours often bleed intermittently, so careful history taking is vital if other concerning symptoms are present. Helpful hint: NICE NG12...

read more
CPD for professionals working in Greater Manchester

CPD for professionals working in Greater Manchester

Tuesday 27th April 2021 Have you secured your place at your next online cancer education event? GatewayC Live: Greater Manchester is a programme producing 30-minute live broadcast webinars developed for all healthcare professionals working in Greater Manchester. Sign...

read more

Related Posts

Cancer Keys: Rectal bleeding

Cancer Keys: Rectal bleeding

Potential pitfall: Rectal bleeding is a key symptom of colorectal cancer, but there are also a number of other benign causes. Tumours often bleed intermittently, so careful history taking is vital if other concerning symptoms are present. Helpful hint: NICE NG12...

read more