Cancer Keys: The two tests that will diagnose at least 90% of myeloma patients

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Myeloma investigations

If you are suspicious of myeloma following blood results, there are two pertinent investigations that can be ordered in primary care to give a strong case for referral:

1. Serum protein electrophoresis test
2. Bence-Jones protein urine test

Potential Pitfall

If you test for serum protein electrophoresis alone, you will identify only 2/3 of patients.

Helpful hint

Most patients with untreated myeloma have a monoclonal immunoglobulin peak in serum, urine, or both. A combination of serum protein electrophoresis and Bence-Jones protein urine test will diagnose up to 95% of patients with myeloma without any form of imaging. NICE NG12 guidelines suggest making a suspected cancer referral for patients whose investigation results indicate myeloma.

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Latest from the Blog

Meet the specialists: diagnosing ovarian cancer Q&A

Meet the specialists: diagnosing ovarian cancer Q&A

15th January 2021 Missed our free GatewayC webinar on Diagnosing Ovarian Cancer? Watch our recording here. In this webinar, GatewayC met Professor Gordon Jayson, Professor of Medical Oncology at The Christie NHS Foundation Trust, who answered key questions from our...

read more

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Potential pitfall: A migraine headache is typically a unilateral, frontal, throbbing headache which may be associated with photophobia or phonophobia. Although the intensity can vary, the characteristics of the headache tend not to change. Helpful hint: The most...

read more