Cancer Keys: The two tests that will diagnose at least 90% of myeloma patients

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Myeloma investigations

If you are suspicious of myeloma following blood results, there are two pertinent investigations that can be ordered in primary care to give a strong case for referral:

1. Serum protein electrophoresis test
2. Bence-Jones protein urine test

Potential Pitfall

If you test for serum protein electrophoresis alone, you will identify only 2/3 of patients.

Helpful hint

Most patients with untreated myeloma have a monoclonal immunoglobulin peak in serum, urine, or both. A combination of serum protein electrophoresis and Bence-Jones protein urine test will diagnose up to 95% of patients with myeloma without any form of imaging. NICE NG12 guidelines suggest making a suspected cancer referral for patients whose investigation results indicate myeloma.

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Latest from the Blog

Assessing peripheral neuropathy

Assessing peripheral neuropathy

Thursday 18th February 2021 It is important for primary care practitioners to explore and assess peripheral neuropathy carefully by evaluating the level of impact on the patient, both physically and emotionally. Many individuals receiving chemotherapy are nervous...

read more

Related Posts

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Neutropenic sepsis is a potentially fatal complication of anticancer treatment (particularly chemotherapy). Helpful hint: NICE have produced a COVID-19 rapid guideline on the delivery of systemic anticancer treatments. If patients present with COVID-19 symptoms this...

read more